Immune privilege persists in eyes with extreme inflammation induced by intravitreal LPS
نویسندگان
چکیده
منابع مشابه
IL-6 antagonizes TGF-beta and abolishes immune privilege in eyes with endotoxin-induced uveitis.
PURPOSE To determine the immunosuppressive status of aqueous humor (AqH) from mouse eyes afflicted with endotoxin-induced uveitis (EIU) and to identify the relevant cytokines responsible for immunomodulatory activity within EIU AqH. METHODS Bacterial lipopolysaccharide (LPS) was injected into hind footpads of C3H/HeN mice; and AqH, collected at 6, 12, 24, and 48 hours, was evaluated for conte...
متن کاملImmune privilege induced by regulatory T cells in transplantation tolerance.
Immune privilege was originally believed to be associated with particular organs, such as the testes, brain, the anterior chamber of the eye, and the placenta, which need to be protected from any excessive inflammatory activity. It is now becoming clear, however, that immune privilege can be acquired locally in many different tissues in response to inflammation, but particularly due to the acti...
متن کاملLPS-induced renal inflammation is prevented by (−)‐epicatechin in rats
This work investigated the capacity of (-)-epicatechin to prevent the renal damage induced by LPS administration in rats. Male Sprague Dawley rats were fed for 4 days a diet without or with supplementation with (-)-epicatechin (80mg/kg BW/d), and subsequently i.p. injected with lipopolysaccharide (LPS). Six hours after injection, LPS-treated rats exhibited increased plasma creatinine and urea l...
متن کاملLoss and restoration of immune privilege in eyes with corneal neovascularization.
PURPOSE To delineate the time course for loss of immune privilege after induction of corneal neovascularization (NV), and to test whether treatment with angiostatic agents can restore the eye's capacity to induce anterior chamber-associated immune deviation (ACAID). METHODS Corneal NV in murine eyes was induced by placement of intrastromal sutures. At different time points after NV induction,...
متن کاملEffects of experimental ocular inflammation on ocular immune privilege.
PURPOSE To determine whether the inflammation of endotoxin-induced uveitis (EIU) and experimental autoimmune uveoretinitis (EAU) alters key in vivo and in vitro parameters of ocular immune privilege. METHODS For EIU induction, C3H/HeN mice received 200 microg lipopolysaccharide (LPS). For EAU induction, B10.A mice were immunized with 50 microg interphotoreceptor retinoid-binding protein (IRBP...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2001
ISSN: 0014-2980,1521-4141
DOI: 10.1002/1521-4141(200112)31:12<3806::aid-immu3806>3.0.co;2-m